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Letrozole, sold under the brand name femara (by novartis) among others, is an aromatase inhibitor which is used in the treatment of hormonally-responsive. — in healthy postmenopausal women, single doses of 0. 5 mg, and 2. 5 mg letrozole suppress serum oestrone and. — in healthy postmenopausal women, single doses of 0. 5 mg and 2. 5 mg letrozole suppress serum oestrone and oestradiol by 75 to 78% and. Letrozole is a non-steroidal aromatase inhibitor. It inhibits the aromatase enzyme by competitively binding to the haem of the aromatase cytochrome p450,. Patients in a (92) were given le, 5mg from day cycle 3-7/3 cycles and ce, 0. Those in b(88) received only le, same dose & duration. 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